(generic for Desyrel)

Trazodone was introduced as an antidepressant.  It also works well for sleep and for pain.  The dose is variable and depends on the person.  Ordinarily one starts with a low dose and increases it slowly.  One can safely use this with pain medications, non-steroidals and muscle relaxants.  One should avoid Valium, if possible, since it seems to counteract the antidepressants.  This should be used at night since it causes drowsiness.  Do not drive after using this medication.

The following is the package insert.  It is complete
and lengthy but not easily understood

Trazodone Tablets

A mood elevating medicine used to relieve mental depression.

Precautions: DO NOT USE if you are allergic to this medicine.

BEFORE USING THIS MEDICATION, tell your doctor or pharmacist if you are pregnant or breastfeeding; or if you are taking, will be taking or stop taking any prescription or nonprescription medicine; or if you have any other medical conditions.

Side Effects: Every medicine can cause side effects, but many people have no, or minor, side effects. Tell your doctor or pharmacist if any of the following occurs: nausea; vomiting; diarrhea; constipation; dry mouth; drowsiness; anger; hostility; sleeplessness; nightmares/vivid dreams; confusion; decreased concentration; dizziness; fatigue; headache; tremors; impaired memory; nervousness; incoordination; blood pressure changes; irregular heart rhythm; pounding in the chest; chest pain; ringing in the ears; blurred vision; nasal congestion; rash; clamminess; sweating; blood in urine; incontinence of urine; prolonged painful erection; premature ejaculation; changes in sex drive; impotence; missed menstrual periods; breast enlargement; breathing difficulty; weight changes; swelling; aches and pains; fainting.


  • Take with food.
  • If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to "catch up," unless advised by your doctor. If more than one dose is missed, contact your doctor or pharmacist.
  • May cause drowsiness or dizziness. Use caution while driving or performing other tasks requiring alertness and coordination.
  • Avoid alcohol or drowsiness-causing medications (eg, tranquilizers, pain medicine, antihistamines) while taking this medicine.
  • Male patients with prolonged and painful erections should immediately discontinue the medication and consult a doctor.
  • May cause dry mouth, irregular heartbeat, shortness of breath, nausea and vomiting. Notify your doctor if these become pronounced.

This information is advisory only; it does not contain all information about this medicine. If you have any questions about your medicine, ask your doctor, pharmacist or healthcare provider.

Copyright 1993 by Facts & Comparisons, used by permission of Southwood Pharmaceuticals

Go to the next chapter on orthotics.

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Last modified: 07/27/08